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When it comes to goals and new year’s resolutions, weight loss is right up there with winning the lottery. This is why people download apps, get gym memberships, and subscribe to magazines. But for some people, weight loss is a matter of life and death.

We’ve gathered some of the most compelling personalities from TLC’s My 600-lb Life, one of television’s hardest-hitting weight loss shows. When people end up there, they’re usually knocking on death’s door. We now look at participants on the show, the issues that caused them to gain weight, and their journey towards losing weight at last!

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